it is up to you how you quilt it- it also depends on your batting- some batts have to be quilted every 2" which would probably mean you have no choice- other batts allow up to 10" between quilting lines- so you may not have to - you could just quilt around them- so first- check your batting package- and see how close you need to quilt- then look at the quilt and form a plan in your mind.