I'm doing raw edge applique using glue or small pieces of Steam-a-Seam2 to hold my shapes down; then I straight stitch the around the edge of the shape. I don't like the stiffness of all over fusible. I haven't tried Mistyfuse yet. It seemed kind of pricey when I looked at it last year but when I do a piece that is more a "formal" applique pattern, I'll try it. I'm doing funky houses now so the straight stitch is perfect.
Like Peckish I quilt around my shapes & add more quilted details to shapes. Oh, and I spray starch the dickens out of everything...background fabric and all shapes...before I start placing the shapes, then press the glue dry, spray starch again -front & back. Experiment and have fun until you find the techniques you like...there's no wrong way to applique or quilt!