With an unlimited budget, the ultimate setup for me would be an A-1 machine with Intelliquilter. That combination is $30,000+, depending on the options selected. With a more limited budget, I would select an Innova 18" machine with Lightening Stitch option and Qbot. That combination would run around $16,000, including the computer software to digitize your own designs. By the way, I currently have an older Tin Lizzie 18 with Qbot. A used setup like mine would run around $10,000, or less.
But do some thorough research on your own and try out each system for yourself. Each person has their own likes and dislikes. It is quite a bit of money to put into one of these systems, so be sure to find the one that fits YOU best.