I have no idea but try a sample and see. Sounds like a handy idea for sure. The only way I could see it being a problem may be if it was supposed to be fused to the back of t-shirts for a quilt. In that case, I think the whole idea is to stablize the stretch of the T-shirt fabric. I don't know if the spray is strong enough for that but again try a sample and see. Good Luck!