Test wash the thread colors frist, if from the original skeins, to see for bleeding...then can use very mild detergant or soap...I also love the J & J baby shampoo, easily controlled for spot treating. Ox products work well, but make sure that the concentration is not too strong, as I have seen a strong solution or direct contact of the graduals weaken the fabric very much. Also gentle handling, as in most cross-stitch there are not knots in the sewing of the blocks. It should make beautiful quilt...please post pictures when done.