I used gloves (like Machingers) until I heard about glycerine. I tried it because I like to try ideas that seem "odd" but it works for me. You put 2-3 drops of glycerine on your fingertips and rub it in with your thumbs--your thumb and fingertips will feel a bit "tacky". This enables you to guide the quilt but you can still thread needles, pick things up etc.etc. I've never experienced a problem with it staining anything or leaving a residue on the quilt.
I do mostly smallish pieces and a LOT of raw edge applique and this works better for me than the gloves do because some of the work is pretty precise and you don't have the added bulk of the gloves. A small bottle of glycerine will last a long time and is readily available at your local chain pharmacy or Wally World. I'm unaware that there would be any adverse health effects from using it but I've never checked.