Tying the quilt sounds fine. I did one recently using Warm and Natural Batting and tying it with perle cotton. It was easy enough to do but wasn't as large as a queen.
I recently did a combination of SID and machine tacking on an almost-queen size. The blocks were about 5.5" and the batting was rated for hand tying or quilting at 4" intervals. So I did the SID and then tacked in the center of each block. The batting was Hobbs Polydown and it was SO much lighter and easier to maneuver through the machine. It will scrunch way down then fluff back up.
AnitaSt