Have you practiced free-motion quilting enough to feel comfortable doing a large stipple? If not, a queen-size quilt probably wouldn't be the best place to try it out.
I personally find stitch-in-the-ditch too difficult so I refuse to do it anymore. It's because I'm a perfectionist and am bothered by the inevitable imperfections trying to stay exact. Plus my eyes get tired looking so closely.
If you have a machine that can do a serpentine stitch, you might want to make a sample of that to see if you like it. Basically it is SID except that the pattern of the stitch weaves back and forth over the ditch. Someone may be able to post a sample so you can see what it looks like. The weaving back and forth makes it a much more forgiving pattern than a straight stitch for SID, and you still get to sew with the feed dogs up.
On a different note, one of the biggest problems for machine quilting a large quilt on a domestic machine is the bulk under the arm. I posted a method of splitting the batting and quilting in thirds that cuts way down on the bulk. If you scroll down through the following thread, you will see my post with instructions on how to do this:
http://www.quiltingboard.com/main-f1...ml#post4938857