My DH helps me when I need to do this. We use the hardwood bedroom floor and tape the backing down with masking tape, making sure it is smooth and straight. We then layer the batting and quilt top over it. I fold back the top 2 layers only to the half way point or middle of the quilt and he sprays the batting lightly. Smooth the batting down and he sprays the top side of the batting so I can smooth down the quilt top. Then we do the same for the other half of the quilt.
As for the clean-up--We had a great deal of trouble getting the overspray off the wood floor but we have found that if we wet a few old washcloths with very hot water and clean it up within an hour---it all comes off cleanly. No more residue left behind.
BTW-I use the 505 spray and love it.