I recently finished a similar quilt for my daughter's friend as a housewarming gift. I machine quilted all squares from opposite corners, making an 'X' in each box. It came out really well - it was the first time I machine quilted. If you go that way, just remember to baste and pin well and start in the middle working your way out so you don't get 'bubbling'. Of course, this is just my humble opinion, but it did work out well for me. Can't wait to see what you decide to do with yours!!