I have seen posts from hand quilters who spray baste. It doesn't seem to be a problem for them, but it may depend somewhat on the brand of spray.
I too am thinking that a heavy thread like this is going to require a needle with a pretty big eye, which in turn is going to be very difficult to push through the layers. Definitely test out thread and needle on a practice piece first. You may want to go to something smaller, even for big stitch.