My vote is EQ6. I love it! It's so versatile and you can download fabrics so you can build a "virtula stash" to audition fabrics...which really helps me since I'm so picky about what goes and what doesn't. I also like the option of rotary cutting, PP, templates, etc. I will never live long enough to make all the quilts I want so by designing them it makes me feel like I'm getting closer. :) :)
Oh, I forgot--there's 24/7 tech support :)