In PF and surrounding areas you can visit Machine Quilting by Iva, The Cherry Pit, and Mountain Stitches by Susan. Iva's and Cherry Pit are fairly close together and I think they are really in Sevierville. Susan's is in Gatlinburg.
If you come down I-75 you can stop in LaFollette at The Quilt Patch (I've never been here, but have heard it's a nice shop). There is a shop in the north part of Knox County called That's Sew Mary Jane. On the east side of Knoxville off I-640 is Dizzy Divas. I don't know of anything else in a direct path to PF.
Have fun and enjoy your visit to our corner of the world!
Darren