I prefer Quilters Dream of poly. It is what I started out with and is very easy to handquilt with. I have tried Warm and Natural and find it little difficult to catch the bottom layer. Hobbs' 80/20 would be my second choice. My quilting ability is beginning. I have made several quilts and handquilted all of them. My stitches are consistent but still need to be smaller. LOL. I don't know about the needle size--eyes require a bigger hole.