I would lay them out in the pattern that I wanted and then put them together in pairs and then put the pairs together into four patches. Then I would put the four patches together in pairs and the pairs of four patches together into giant four patches until you have the quilt top in four giant sections and then sew the top half together and the bottom half together. One of the biggest advantages to putting a quilt top together this way is there's only one full width seam to sew and you only have the whole thing on the machine for one seam and then borders. It will also come out straighter overall.