How about 'I Spy" for her. Using things that she likes or remember her of memories. You could have some blocks with photos in them. Making the blocks bigger. Make it colorful and use some fabric or garments of her family, Mother's dress or Daddy's shirts. Backing such be soft like flannel or polar. Good Luck. What ever way you go. She will be comforted by the quilts. My prays and thoughts are with your family. Let us know what going on.
God Bless