I've only ever put real bindings on two quilts (others were either pillowcase type or turn back to front types), and they were both this year. The first was one I made in a class, and I did the whole thing on the machine, and was not happy with it. The stitching wasn't that even and was very obvious. The second quilt is a baby quilt, made out of 20 white fabric squares decorated with fabric markers, crayons, etc (from ladies at church). After not liking the binding on the first quilt, I decided I'd have to do this one by hand, and was dreading it, because my hand stitching isn't neat and even. I watched the Schamber (?) binding video, and while I didn't do the glue, etc., I was very intrigued by the ladder stitch she used. So I decided to give that go, and LOVED it! It was very easy and is truly invisible. This still wouldn't work for those who have physical problems with handstitching, but for those who can handstitch and are concerned about their ability to make tiny, even, neat stitches, this is a lifesaver.
But...now that I've read everyone's comments, I'm concerned that it won't hold up under use and washing. I plan to try some of the machine binding tips that are given here for future quilts.