I try to make baby quilts for each new baby in our church, plus my son is 27 now and has lots of friends who are now married and having babies.... I always use cotton. The reason? I'm scared to try sewing flannel or Minkie! I have seen my sewing skills improve as I've made more and more, but since I'm just improving on that, I don't want to risk going backward! Have fun with whatever you choose!