I would say no. I once made a quilt out of assorted fabrics on commission. It was out of her deceased mothers clothes. There was everything in there from a Nylon lycra bathing suit, to knits, fleece, sweatshirts and cottons. It was do-able and she was very pleased with the final quilt but I will never, ever do it again. I can pretty much assure you that while it can be done, you will most definitely NOT enjoy the process.