I have done it a few times and not just stitch in the ditch, but FMQ as well. It takes a bit of thought to make sure that you position your quilt so that you don't have the majority of it in the harp space. As for sandwiching, I don't have a lot of floor space so I sandwich half of the quilt and then do the other half after I have spray basted and ironed the first half. the sandwiching is the worst part of it but it can be done.