It can be done, just not easily or at least I don't think it's easy, and I certainly can't FM good, but I can get it done. There are a couple of different ways that I've tried, 1-quilt as you go, 2- you put the sandwich together, to make sure everything's going to fit, then fold the top into 3rds, then cut the batting in large wavey curves, mark right/left and top or bottom, then remove that section, do the same for the other side, then quilt the center but leave some space so that you can hand stitch the batting sections back on, then quilt each section. I've done it both ways and did get them done, but I personally didn't find them a whole lot easier than wrestling with the whole big quilt.
You don't say if your quilting table is the same/approximate height as your machine, if not, that's the first thing I would recommend. Also, I read about the silicone "pad" for your machine, the only thing is, it's just a small pad. I've also read about the fabric safe silicone spray, that you spray on the bed of your machine and quilting table. Just for the heck of it, I bought a can. I COULDN'T BELIEVE the difference it made in being able to MOVE the quilt. I highly recommend it, and when I'm at a quilt/fabric store, I'm going to get several cans of it. GOOD LUCK and I hope that these tips will help you.