You can use two fabrics , but I would be cautious on a quilt that size it could end up not meeting your expectations. I like log cabins for using scrap fabrics the aray of colors always plays well in this pattern. Take a look at the log cabins in the gallery of quilts here it can help you get some visual ideas .
Here is the link on this site
http://www.quiltingboard.com/blogs/q...enu-b2181.html