I also have arthritis in my hands - one hand is braced because of it.
I thought that the Accuquilt would be the answer for me so I tried it out at the LQS - not for me. Too much to get the fabric just right and then try to hold it and crank.. I suppose it would get easier with time.
Make sure you try it before you buy it.
I found an ergonomic rotary cutter that works great for me and I lean on the ruler with my other arm Works for me.