I am priarily left-handed, but have learned to use either. Have had to teach myself most craft forms because righties would just confuse & frustrate me. Cutting with the quilting rulers is the biggest struggle for me. The only place big enough for me to use my mats is the stove top with the cover down & the light is on the right side. When I try to cut on the left side, I can't see the lines because I & the hood are in the way. I struggle, but I get it done! Not going to let the righties get the better of me! LOL!