I would position it to save the most fabric in one piece. Off center seams may not be asthetically pleasing, but once you get it quilted, the seam usually doesn't show up much. And unless it is a show piece, what does it matter where the seam is. Quilts were originally made utilizing the fabric to the utmost. That is why they were pieced scraps in the first place. That's my humble opinion, and I am sticking to it. :roll: