I have used the same cutters for over 25 years, afraid they are not what you could call ergonomically correct, but then I really don't use them day in and day out. Bought them from a store called "FedCo." One came with the Olfa cutting mat, which I also still have and use at times because it fits perfectly on my ironing board when I am cutting smaller pieces. I cut out the quilt and then sew. If the cutting starts to bother my hand then I stop and do something else for a while. Guess I am one of the lucky folks. Both my mom and my sister have been bothered with carpal tunnel syndrome. I worked in an office for over 38 years - and just had bouts off and on.
Saying my thank you prayers because it can be a truly crippling condition.