I handquilted a T-shirt quilt for my stepson. It took a while, and I had some sore fingers, but it CAN be done. I used a 1" diagonal grid pattern on the T-shirt panels and a Greek Key design in the sashings and borders. As for using pantos, I don't see why you couldn't use them. Get some thin roll paper (doctor's office table paper works great), put the paper on top of the panto and trace the design. Set up your sewing machine with a size 16 needle, NO thread and a med. to long-ish stitch length. Sew on the lines on the paper to perforate the paper. You don't need to trace the entire panto, just a few repeats of the pattern. Once you have the paper perforated with a few repeats of the pattern, lay it on top of your quilt top and use pounce powder to transfer the design to the quilt top. Since you are handquilting, I wouldn't transfer big areas all at once, as the powder will rub off with handling. when you finish quilting one section, transfer the pattern on to the next section that you will be working on and so forth. As for the interfacing, you NEED to use it. The t-shirt fabric is VERY stretchy without it and will cause you all kinds of problems. You may not be able to get tiny little stitches, but it CAN be done. There are probably other ways to do this, but this is the way that I would do it. Good Luck!