It depends on what you are going for. If you like your designs to be EXACT from place to place on a quilt, then the computer guided LAer is your answer. If you want variety, even on a design that repeats, then hand guided is your choice. There are +'s and -'s to both methods, and many LAers will mix both techniques within the same quilt. I've seen questionable stuff from computer guided systems, and absolutely drop dead gorgeous from hand guided. One is not necessarily better than the other.
I just realized I've been no help at all!!!! 8)