Sewing with Nancy did a whole segment on photo quilts last year? It may be recorded from another year but you could check her site to see if she has any info on it. I've never done one but the ones I've seen that I like the best, have smaller photo surrounded by pieced blocks.If you do the photos too large then you have to decide if you want to quilt through them if the batting requires it. I don't like how the bigger photos always look puffy/wrinkly without quilting in them. I have seen a few with a stipple right through large photos but I think it spoils the picture but that is just my opinion.