I think making scrappy quilts is all about playing with what you have and seeing what looks interesting together. It's your quilt, so please yourself.
Lately I have tried Bonnie Hunter's method of cutting my scraps into usable sizes and piecing them as leaders and enders while sewing a different quilt. I made, among other things, about 450 3" squares. Then I sorted them into pairs, alternating lighter and darker, and started making 4-patch blocks. I have enough to make some sort of quilt, but haven't decided for sure on other parts of it. I'm thinking of a variation of an Arkansas Crossroads pattern. The thing is, it's very encouraging to me to have those 4-patch blocks instead of a pile of scrambled bits. Also, the gradual coming together of them is relatively painless and entertaining, whereas if I'd started off with a specific plan to make a little quilt with almost 100 different fabrics in it - in small pieces - it would have looked like a much bigger challenge.