I have made several quilts with pictures. For large pictures, I kept things simple with just sashing (I used 3 strips of 2 colors with stars for cornerstones). For the smaller pictures, I used filler blocks (just took a block I liked). I sashed around the pictures to bring them up to the size of the filler block. The Warm Wishes pattern makes a nice frame for pictures. I would get some grid paper and sketch.