I have hand embroidered with silk thread through fused pieces (Wonder Under). No problems at all either with the thread fraying or it being hard to work through...and Wonder Under is a bit tougher than Misty Fuse. You should be just fine. Why not try a sample shape first? (and, yes, I know you probably mean machine satin stitch)
Last edited by ghostrider; 07-11-2012 at 11:23 AM.