I've made small lovies from Minkee fabric. When making the 'lovies' I use 2 pieces of the fabric put it 'wrong sides together' and then I put small tabs of grograin and satin ribbon, in different colors around the perimeter. Then I sew it together leaving a turning area. After I turn it I sew it closed. I guess I could use a serger, but I avoid getting it out! A small zig zag does much the same thing (other than cutting it at the same time). If you are comfortable using a serger, I say go for it. If you don't like the results change. I do remember that sometimes with a knit the serger tends to lettuce the edges. If that is what you are going for good, if not well. Test out a small amount on the serger and see what you think.
I think Minkee is like corderoy. It can be messy, but I don't think it runs, and I think it is pretty stable as a fabric.