joanne's gingham may not be 100% cotton --- but that doesn't make (most) not----i've bought many many bolts of 100% cotton gingham over the years.
it makes nice fun appliques, i generally use a fusable lightweight woven stablizer on the back for appliques- (placed on top-fusable facing right side of fabric- sew all around- make a slit in stablizer & turn right side out- gives a finished edge) because the edges do tend to fray a bit
also works well for pieced blocks- it's a personal choice if you want to cut with the lines or not-
i made lots of little girl dresses, skirts & little boy shirts out of gingham back in the day (when they were little)
also raggedy andy shirts-
i think a couple of my granddaughter's may have a quilt or two with gingham but i don't think i have any pics- will have to do some looking