After many many years of sewing, I do think there is a difference in thread. For years I used only Coats & Clark, I have even used Serger thread for sewing and piecing....However I rescently did some extensive research and have now 'discovered' Superior thread. I order direct from the company, they are in Arizona. I am currently using their "So Fine 50 wt", and love it. Very very lint free, super strong, and nestles down into the fabric rather than sitting on top. I purchased their 3,000 yard + cone which will probably last a life time. They also make "King Tut" machine quilting thread, which is outstanding. Go to their website, they have a TON of information about the different kinds of thread, what thread for what function and also about the different kinds of needles....Super great information.