I'm a Janome fan. I have an older Janome QC6260, but upgraded to the Horizon7700 shortly after they came out. I LOVE the Horizon. I make bags, home dec, also, but quilting is what keeps me going. The extra space on the Horizon, the lighting, the walking foot built in, the oodles of stitches, the extension table, and especially the thread cutter make it so much fun. It's like when you get a car with power windows, locks, remote entry etc. When you go back, you really miss the "bells and whistles"..
I'd really look at your budget. If you can afford to "go big" on your machine, I would, because if you think you're going to increase the amount of sewing/quilting you're going to do, you don't want to "outgrow" your choice and have to buy another machine in the near future.
That's just my opinion. Others will differ. That's why you ask around, right?