That is tough question because there are so many possible answers and what works for me may not for you. I like Hobbs 80/20 fusible batt that you dry iron to make the sandwich. I have picked up 505 spray basting to try that but you do need a sizable spot to spray that if you have a large quilt. Some people like the Sharon Scharber (sp) method of using boards to needle bast a section at a time. There are still some people would like to use safety pins to put the 3 layers together but I always got tucks in the back doing that. If you are able to watch YouTube videos, there are some good ones to watch.