I worked for a company that notified the utility companies to go and mark their underground lines before people or companies would begin digging. I worked from home with the exception of 1 week per month when you had to go into the office and have meetings, do audits and just spend time in the group/office environment. It was not had to focus and work because you were on the phone most of the time or required to be available to take calls. It is not for everyone, though. The jobs are definitely out there but the companies are becoming more selective.
One benefit is that, I found, when you are not self-employed and working from home it is very easy to leave that work behind. I never had a problem with that. I have a dedicated office and when I logged off of my phone I closed the door and that was it. I think that is essential and many companies will require that you have a dedicated area for work.
Think about what your skills are and then look at companies that would need those skills.