I think if you pick clothing that hasn't had much use it works well for quilts. Men's shirts can have over 2 yards of usable fabric in them. Full skirts also have a lot of fabric. You can tell if there is a lot of wear in them just choose carefully. A lot of men's tropical print shirts are cotton and would be a lot of fun to use. Check the label to be sure they are cotton or at least cotton blend. If you are going to hand quilt use only cotton since it is easier to hand quilt than blends are. Remember our grandmother and great grandmother used what was available for quilting. If used clothing is the most available for you than "go for it".