Two weeks ago I finished a baby quilt from a panel that was meant to be a fabric book...Pokey Little Puppy. I made a Warm Wishes quilt out of it, alternating 13 "pages/cover" from the book with the Warm Wishes block. Turned out cute, 25 blocks altogether.
With lots of pages from an alphabet block, simple sashing might be good.
One thing I've found with panels is they are often not square and if you prewash that can make it worse. I always prewash, but for the Pokey Puppy quilt I did not. I carefully squared up each page into a block. I washed the finished quilt with a color catcher in case there was any bleeding from the fabric.