I am more interested in color and pattern. I find it very difficult to make the types of quilts I like with just Joanns. Occasionally I will find a coordinating color or print to use but not as often as an LQS.
Joanns and Hobby Lobby can carry excellent fabric but will never substitute for a LQS when it comes to having the variety for design and the deep wonderful saturated colors they can buy.
This is coming from someone who loves older "stored in closet" types of fabric from garage sales, etc. I still haunt LQS sales of all kinds for fabric to go with these older scrappy fabrics.