One way to use a large panel when you have fussy cut squares or blocks of different sizes that coordinate with the panel would be to finish the quilt with solid colored borders to the size you want the quilt to be, then add the fussy cuts ticker tape style on top of the solid colored borders. This solves the problem of the blocks being different sizes quite nicely and you can center your fussy cuts exactly as you prefer.Usually the borders would be the same color.