Farmquilter, actually it isn't all that difficult. If you have the Lil Twister tool, it comes with instructions and a layout that is 4 blocks by 6 blocks. I used two different fabrics and made 3 4-patches of each color. Then layout your 4-patches in checkerboard fashion. The horizontal rows have 2 4-patches, one of each color. Then the second row the same but the colors are switched. The 3rd row is the same as the 1st row. Then add your 3" border all around.
When you cut the twister blocks, you will end up with what you see in the pics. Just take out the solid center blocks and replace with different fabrics or photos.