I don't ever feel sad when I use up the last of a favorite fabric. Once in a while I'll wish I had more of it. I have had fabrics though that I thought I'd never see the end of and I'm glad when I get it used down low enough I don't feel bad for tossing the rest.
Since I've been quilting for several years now when I run across a fabric that I know I'll use yards and yards of it eventually I buy yards and yards of it!