I took the biggest bedroom for my sewing room since its the only downstairs bedroom.
And I don't live alone. I have a hubby and 2 little boys. It's the only way to keep them out of my stuff and allow metro have a place to work while they are up, and so my crafting noise doesn't keep them awake. Dh and I only use our room for bed anyways, so this is a much more useful way to use our space.