I've made about 24 baby quilts with either fleece, flannel or minky as backing. With some of the minky ones I used a piece of flannel as batting, but with fleece, no batting at all. I use spray basting & machine quilt them. It's a piece of cake. Fleece is great because it glides over the machine. Check your machine for lint when you're finished.
With satin blanket binding they're irresistible.