I would and don't keep a guest room. I live in a small house and barely have room for us. Our oldest Granddaughter almost 26 lives with us and has the past 7 years. She has the largest room (lots of stuff). When she moves that will be my sewing room. She is trying to get through college on her own and working. She is getting close. She goes to school nights and weekends. Had gotten wrong information before and that set her back a bit. I'm patiently waiting.
That being said I think you should use your house to the fullest for yourself and use it all. Let guest worry about themselves.