I would say especially since you're using varigated thread it should work fine.
I was feeling a little over run by all the spools of thread in my sewing room. So, I recently quilted 2 quilts (a king and a queen) with the goal of using up as many of those spools as possible. I made sure to use colors that complimented the fabrics and tried to use similar colors/tones top and bottom at any given time. I ended up using up 25 spools. The quilts look great and the thread stash is a little better.