Heaven's yes! It does happen and that is a valuable lesson to remember. (Mental note to self...LOL) I try to make one block up to make sure that the pattern is right before cutting multiple block sets out. It can be so heartbreaking to find it out after you have cut a whole quilt out.
One in particular that comes to mind was the Rythum and Blues quilt from red rooster. A free pattern for thier site. Thank goodness I had enough fabric to re-cut!