I have made lots of tied Baby Quilts and tied them every 4 " apart... I have tied Corners as well as in the middle of the blocks... sometimes follow the design around the edges of the Animals or Toys on the Quilts. for them I used the Poly batting so I wasn't too worried about it shifting... Just remember to dry on Low heat and only wash just the quilt in a Front loading washer... One of my Baby Quilts lasted through 4 children..... With a larger Quilt a little closer together would be Good...